Abstract
TAL1 gene rearrangement is the most common genetic defect associated with T cell acute lymphoblastic leukaemia (T-ALL). Tumour-specific rearrangements of TAL1 arise as a result of either chromosome translocation or local DNA recombination. TAL1 gene products possess the basic helix-loop-helix (bHLH) motif, a DNA-binding domain common to several known transcription factors. The bHLH domain of TAL1 is especially homologous to those encoded by TAL2 and LYL1, distinct genes that were also identified on the basis of chromosomal rearrangement in T-ALL. Thus, TAL1, TAL2 and LYL1 constitute a unique family of bHLH proteins, each of which is a potential mediator of T cell leukaemogenesis.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Basic Helix-Loop-Helix Transcription Factors
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Chromosomes, Human / ultrastructure
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Consensus Sequence
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / physiology*
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Gene Expression Regulation, Leukemic
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Gene Rearrangement, T-Lymphocyte*
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Genes, myc
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Helix-Loop-Helix Motifs / physiology*
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Humans
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Leukemia-Lymphoma, Adult T-Cell / genetics*
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Mice
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Molecular Sequence Data
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Multigene Family
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Neoplasm Proteins / genetics
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Neoplasm Proteins / physiology*
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Proto-Oncogene Proteins*
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Recombination, Genetic
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Sequence Alignment
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Sequence Homology, Amino Acid
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T-Cell Acute Lymphocytic Leukemia Protein 1
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T-Lymphocytes / metabolism
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T-Lymphocytes / pathology
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Transcription Factors*
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Translocation, Genetic*
Substances
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Basic Helix-Loop-Helix Transcription Factors
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DNA-Binding Proteins
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LYL1 protein, human
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Lyl1 protein, mouse
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Neoplasm Proteins
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Proto-Oncogene Proteins
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T-Cell Acute Lymphocytic Leukemia Protein 1
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TAL2 protein, human
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Tal1 protein, mouse
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Tal2 protein, mouse
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Transcription Factors
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TAL1 protein, human