No rearrangements of the CHOP gene in malignant fibrous histiocytoma

M Nilbert; N Mandahl; P Aman; A Rydholm; F Mitelman

doi:10.1016/0165-4608(94)90133-3

No rearrangements of the CHOP gene in malignant fibrous histiocytoma

Cancer Genet Cytogenet. 1994 Feb;72(2):155-6. doi: 10.1016/0165-4608(94)90133-3.

Authors

M Nilbert¹, N Mandahl, P Aman, A Rydholm, F Mitelman

Affiliation

¹ Department of Clinical Genetics, University Hospital, Lund, Sweden.

PMID: 8143276
DOI: 10.1016/0165-4608(94)90133-3

Abstract

The human transcription factor gene, CHOP, which maps to 12q13, was recently shown to be disrupted by the t(12;16)(q13;p11) in myxoid liposarcoma. The most common soft tissue sarcoma, malignant fibrous histiocytoma (MFH) histopathologically may contain liposarcoma like areas and is often characterized by complex chromosome anomalies, which may include 12q13-15 aberrations, but never as t(12;16). By Southern blot technique, we detected no rearrangements of the CHOP gene in 41 MFH, including five with liposarcoma like areas. Thus, rearrangements of the CHOP gene appear to be specific for myxoid liposarcoma with t(12;16) and are not associated with lipoblastic differentiation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

CCAAT-Enhancer-Binding Proteins*
DNA-Binding Proteins / genetics*
Gene Rearrangement*
Histiocytoma, Benign Fibrous / genetics*
Humans
Nuclear Proteins / genetics*
Transcription Factor CHOP
Transcription Factors / genetics*
Translocation, Genetic

Substances

CCAAT-Enhancer-Binding Proteins
DDIT3 protein, human
DNA-Binding Proteins
Nuclear Proteins
Transcription Factors
Transcription Factor CHOP