Abstract
We have cloned the cDNAs encoding tyrosinase-related protein-2 (TRP-2) from a human melanoma cDNA library. Transient expression of the isolated cDNA in HeLa cells established that TRP-2 is DOPAchrome tautomerase. Human TRP-2/DOPAchrome tautomerase is composed of 519 amino acids with a molecular weight of 59,000 and has about 84% identity with the mouse counterpart.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Cloning, Molecular
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DNA, Complementary / biosynthesis*
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DNA, Complementary / chemistry
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Gene Expression
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HeLa Cells
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Humans
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Intramolecular Oxidoreductases*
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Isomerases / genetics*
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Melanoma / genetics
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Molecular Sequence Data
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Sequence Alignment
Substances
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DNA, Complementary
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Isomerases
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Intramolecular Oxidoreductases
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dopachrome isomerase