Trisomy 21 as the sole clonal aberration in a patient with acute myelomonocytic leukemia with abnormal bone marrow eosinophils and extramedullary involvement

Ann Hematol. 1994 Feb;68(2):93-5. doi: 10.1007/BF01715140.

Abstract

We describe a 30-year-old acute myelomonocytic leukemia patient with abnormal bone marrow eosinophils (AML FAB subtype M4Eo) with extensive extramedullary involvement and, in the abscence of an aberration involving chromosome 16, clonal trisomy 21 in the leukemic blast cells.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aminoglutethimide / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone Marrow / pathology*
  • Danazol / therapeutic use
  • Down Syndrome / complications*
  • Eosinophils / pathology*
  • Humans
  • Leukemia, Myelomonocytic, Acute / drug therapy
  • Leukemia, Myelomonocytic, Acute / genetics*
  • Leukemia, Myelomonocytic, Acute / pathology*
  • Male
  • Tamoxifen / therapeutic use

Substances

  • Tamoxifen
  • Aminoglutethimide
  • Danazol

Supplementary concepts

  • TAD protocol