Acute anuric renal failure: a complication of combined thrombolytic and antithrombotic therapy

Int J Cardiol. 1993 Jul 15;40(3):283-5. doi: 10.1016/0167-5273(93)90012-6.

Abstract

Thrombolytic agents are routinely given to patients with acute myocardial infarction, often in combination with heparin. Genitourinary hemorrhage is an uncommon adverse effect of systemic thrombolysis, and acute azotemic complications are distinctly rare. We describe a case of genitourinary hemorrhage after combined thrombolytic and antithrombotic therapy leading to acute bilateral ureteral obstruction and then briefly review renal complications of systemic thrombolysis.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / blood
  • Acute Kidney Injury / chemically induced*
  • Angioplasty, Balloon, Coronary
  • Anuria / blood
  • Anuria / chemically induced*
  • Aspirin / adverse effects*
  • Aspirin / therapeutic use
  • Combined Modality Therapy
  • Drug Therapy, Combination
  • Hematuria / blood
  • Hematuria / chemically induced
  • Heparin / administration & dosage
  • Heparin / adverse effects
  • Humans
  • Kidney Function Tests
  • Male
  • Middle Aged
  • Myocardial Infarction / blood
  • Myocardial Infarction / drug therapy*
  • Partial Thromboplastin Time
  • Streptokinase / adverse effects*
  • Streptokinase / therapeutic use
  • Thrombolytic Therapy / adverse effects*
  • Ureteral Obstruction / blood
  • Ureteral Obstruction / chemically induced
  • Urokinase-Type Plasminogen Activator / administration & dosage
  • Urokinase-Type Plasminogen Activator / adverse effects

Substances

  • Heparin
  • Streptokinase
  • Urokinase-Type Plasminogen Activator
  • Aspirin