Cloning and sequence analysis of a full length cDNA encoding human mitochondrial 3-oxoacyl-CoA thiolase

Biochim Biophys Acta. 1993 Nov 16;1216(2):304-6. doi: 10.1016/0167-4781(93)90160-f.

Abstract

The cDNA sequence of human mitochondrial 3-oxoacyl-CoA thiolase was determined. The nucleotide sequence contains an open reading frame of 1191 base pairs and encodes an amino acid sequence of 397 residues which exhibits 86.6% homology with that of the rat enzyme. Northern blot analysis gave a single mRNA species of 1.6 kb in the human liver, fibroblasts and intercostal muscle.

Publication types

  • Comparative Study

MeSH terms

  • Acetyl-CoA C-Acyltransferase / genetics*
  • Amino Acid Sequence
  • Base Sequence
  • Cloning, Molecular
  • DNA, Complementary / biosynthesis*
  • DNA, Complementary / chemistry
  • Humans
  • Mitochondria / enzymology
  • Molecular Sequence Data
  • Open Reading Frames
  • RNA, Messenger / analysis
  • Sequence Homology, Amino Acid

Substances

  • DNA, Complementary
  • RNA, Messenger
  • Acetyl-CoA C-Acyltransferase

Associated data

  • GENBANK/D16294
  • GENBANK/L08443
  • GENBANK/X69069
  • GENBANK/X69070
  • GENBANK/X69071
  • GENBANK/X69072
  • GENBANK/X69073
  • GENBANK/X69074
  • GENBANK/X69075
  • GENBANK/X69076