Assignment of the human aggrecan gene AGC1 to 15q25-->q26.2 by in situ hybridization

Hum Genet. 1993 Nov;92(5):516-8. doi: 10.1007/BF00216462.

Abstract

The human aggrecan gene (AGC1) has been localized to 15q25-->q26.2 by in situ hybridization. Although no genetic diseases of connective tissue map to this location, the malignant melanoma-associated surface antigen mel-CSPG is located here; mel-CSPG is a chondroitin sulfate proteoglycan. This raises the possibility that AGC1 and mel-CSPG may be the same gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aggrecans
  • Antigens, Neoplasm / genetics*
  • Chondroitin Sulfate Proteoglycans / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 15*
  • Extracellular Matrix Proteins*
  • Humans
  • In Situ Hybridization
  • Lectins, C-Type
  • Melanoma / immunology*
  • Proteoglycans / genetics*

Substances

  • ACAN protein, human
  • Aggrecans
  • Antigens, Neoplasm
  • Chondroitin Sulfate Proteoglycans
  • Extracellular Matrix Proteins
  • Lectins, C-Type
  • Proteoglycans
  • melanoma-associated proteoglycan antigen, human