Abstract
The human aggrecan gene (AGC1) has been localized to 15q25-->q26.2 by in situ hybridization. Although no genetic diseases of connective tissue map to this location, the malignant melanoma-associated surface antigen mel-CSPG is located here; mel-CSPG is a chondroitin sulfate proteoglycan. This raises the possibility that AGC1 and mel-CSPG may be the same gene.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aggrecans
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Antigens, Neoplasm / genetics*
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Chondroitin Sulfate Proteoglycans / genetics*
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Chromosome Mapping
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Chromosomes, Human, Pair 15*
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Extracellular Matrix Proteins*
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Humans
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In Situ Hybridization
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Lectins, C-Type
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Melanoma / immunology*
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Proteoglycans / genetics*
Substances
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ACAN protein, human
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Aggrecans
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Antigens, Neoplasm
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Chondroitin Sulfate Proteoglycans
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Extracellular Matrix Proteins
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Lectins, C-Type
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Proteoglycans
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melanoma-associated proteoglycan antigen, human