Hyperthyroidism and Down syndrome

Ann Acad Med Singap. 1993 Jul;22(4):603-5.

Abstract

Down syndrome has long been associated with a variety of autoimmune conditions. A significant link has also been described between Down syndrome and autoimmune thyroid disease, usually hypothyroidism. We report two cases of Down syndrome with Graves disease both with significantly elevated titres of thyrotropin receptor antibody and the presence of the HLA Bw46. We also comment on the problems in diagnosis and management of such patients.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Carbimazole / administration & dosage
  • Down Syndrome / diagnosis
  • Down Syndrome / drug therapy
  • Down Syndrome / genetics*
  • Drug Therapy, Combination
  • HLA-B Antigens / genetics
  • Humans
  • Hyperthyroidism / diagnosis
  • Hyperthyroidism / drug therapy
  • Hyperthyroidism / genetics*
  • Karyotyping
  • Male
  • Propranolol / administration & dosage
  • Thyroid Function Tests
  • Thyrotoxicosis / diagnosis
  • Thyrotoxicosis / drug therapy
  • Thyrotoxicosis / genetics

Substances

  • HLA-B Antigens
  • HLA-B46 antigen
  • Carbimazole
  • Propranolol