Abstract
IL-7 is a single-chain 25 kDa protein first identified in bone marrow cultures through its pre-B cell growth factor properties, then also described as a potent T-lymphocyte growth factor. This review relates to the molecular and functional aspects of interleukin-7 (IL-7) and its receptor (IL-7R). We focused on the role of IL-7 in T-cell activation, cytotoxicity generation, leukemic cell growth and immunotherapy.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Cloning, Molecular
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Cytotoxicity, Immunologic / physiology
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Genes
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Graft Rejection
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Humans
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Interleukin-7 / biosynthesis
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Interleukin-7 / genetics
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Interleukin-7 / physiology*
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Leukemia / pathology
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Lymphocyte Activation / physiology
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Mice
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Molecular Sequence Data
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Neoplasm Transplantation
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Neoplastic Stem Cells / drug effects
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Receptors, Interleukin / genetics
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Receptors, Interleukin / physiology
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Receptors, Interleukin-7
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Recombinant Proteins / biosynthesis
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Sequence Homology
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Signal Transduction
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T-Lymphocytes / physiology
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Tumor Cells, Cultured / drug effects
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Tumor Cells, Cultured / transplantation
Substances
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Interleukin-7
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Receptors, Interleukin
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Receptors, Interleukin-7
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Recombinant Proteins