Abstract
The btk gene has recently been identified as the causative gene in X-linked agammaglobulinemia (XLA). This has opened up many new possibilities for the treatment of this B-cell immunodeficiency. Christine Kinnon and colleagues review the high degree of sequence of homology of btk to the non-receptor tyrosine kinases and speculate on putative roles for this gene in B-cell development.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Agammaglobulinaemia Tyrosine Kinase
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Agammaglobulinemia / genetics*
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Animals
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B-Lymphocytes / immunology
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Cloning, Molecular*
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Disease Models, Animal
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Forecasting
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Genetic Linkage*
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Humans
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Mice
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Mice, Inbred CBA
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Protein-Tyrosine Kinases / chemistry
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Protein-Tyrosine Kinases / physiology
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X Chromosome*
Substances
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Protein-Tyrosine Kinases
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Agammaglobulinaemia Tyrosine Kinase
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BTK protein, human