Refined genetic mapping of X-linked Charcot-Marie-Tooth neuropathy

Am J Hum Genet. 1994 Feb;54(2):229-35.

Abstract

Genetic linkage studies were conducted in four multigenerational families with X-linked Charcot-Marie-Tooth disease (CMTX), using 12 highly polymorphic short-tandem-repeat markers for the pericentromeric region of the X chromosome. Pairwise linkage analysis with individual markers confirmed tight linkage of CMTX to the pericentromeric region in each family. Multipoint analyses strongly support the order DXS337-CMTX-DXS441-(DXS56,PGK1).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Charcot-Marie-Tooth Disease / genetics*
  • Chromosome Mapping
  • Female
  • Genetic Linkage*
  • Genetic Markers
  • Haplotypes
  • Humans
  • Male
  • Pedigree
  • Recombination, Genetic
  • X Chromosome*

Substances

  • Genetic Markers