Abstract
The cytogenetic analysis of a radiation-induced osteosarcoma in a 31-year-old male is presented. Complex karyotypic changes with numerical and structural abnormalities, including a del(13)(q12.3q21.1), were observed. This deletion may indicate that loss of RB1 gene (locus in 13q14) may be involved in the development of radiation-induced osteosarcoma.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Bone Neoplasms / etiology
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Bone Neoplasms / genetics*
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Chromosome Deletion*
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Chromosomes, Human, Pair 13*
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Fibula
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Genes, Retinoblastoma
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Humans
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Karyotyping
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Male
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Neoplasms, Radiation-Induced / genetics*
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Neoplasms, Second Primary / etiology
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Neoplasms, Second Primary / genetics*
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Osteosarcoma / etiology
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Osteosarcoma / genetics*
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Radiotherapy / adverse effects
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Sarcoma, Ewing / radiotherapy
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Tibia