Deletion of chromosome 13 in osteosarcoma secondary to irradiation

Cancer Genet Cytogenet. 1993 Aug;69(1):35-7. doi: 10.1016/0165-4608(93)90109-y.

Abstract

The cytogenetic analysis of a radiation-induced osteosarcoma in a 31-year-old male is presented. Complex karyotypic changes with numerical and structural abnormalities, including a del(13)(q12.3q21.1), were observed. This deletion may indicate that loss of RB1 gene (locus in 13q14) may be involved in the development of radiation-induced osteosarcoma.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Bone Neoplasms / etiology
  • Bone Neoplasms / genetics*
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 13*
  • Fibula
  • Genes, Retinoblastoma
  • Humans
  • Karyotyping
  • Male
  • Neoplasms, Radiation-Induced / genetics*
  • Neoplasms, Second Primary / etiology
  • Neoplasms, Second Primary / genetics*
  • Osteosarcoma / etiology
  • Osteosarcoma / genetics*
  • Radiotherapy / adverse effects
  • Sarcoma, Ewing / radiotherapy
  • Tibia