Lack of 5' BCL2 rearrangements in B-cell leukemia

P E Crossen; M J Morrison

doi:10.1016/0165-4608(93)90118-6

Lack of 5' BCL2 rearrangements in B-cell leukemia

Cancer Genet Cytogenet. 1993 Aug;69(1):72-3. doi: 10.1016/0165-4608(93)90118-6.

Authors

P E Crossen¹, M J Morrison

Affiliation

¹ Cytogenetic and Molecular Oncology Unit, Christchurch Hospital, New Zealand.

PMID: 8374905
DOI: 10.1016/0165-4608(93)90118-6

Abstract

We found no rearrangements in the 5' region of the BCL2 gene in DNA samples from 60 patients with chronic B-cell leukemia (CLL). This compares with the presence of these rearrangements in up to 10% of patients in other reports, and suggests that the incidence of 5' BCL2 rearrangements in CLL is considerably less than 10%.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA, Neoplasm
Gene Rearrangement, B-Lymphocyte*
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
Protein-Tyrosine Kinases / genetics
Proto-Oncogene Proteins / genetics*
Proto-Oncogene Proteins c-bcl-2

Substances

DNA, Neoplasm
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Protein-Tyrosine Kinases