Abstract
We purified and sequenced from bovine brain a novel calcium-binding protein. This protein which we named neurocalcin has 3 putative EF hand motifs and a close homology with recoverin which activates guanylate cyclase Ca2+ dependently. Neurocalcin has at least 6 isoforms and is expressed in the central nervous system (CNS), retina and adrenal gland. Considering unique distribution of neurocalcin, this protein may an important physiological role which differs from that of visinin or recoverin.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Calcium-Binding Proteins / genetics
-
Calcium-Binding Proteins / metabolism*
-
Cattle
-
Central Nervous System / metabolism*
-
Molecular Sequence Data
-
Nerve Tissue Proteins / genetics
-
Nerve Tissue Proteins / metabolism*
-
Neurocalcin
-
Receptors, Calcium-Sensing*
-
S100 Calcium Binding Protein G / metabolism*
-
Sequence Homology, Amino Acid
-
Tissue Distribution
Substances
-
Calcium-Binding Proteins
-
NCALD protein, human
-
Nerve Tissue Proteins
-
Neurocalcin
-
Receptors, Calcium-Sensing
-
S100 Calcium Binding Protein G