Chromosome 17 allele loss in hepatocellular carcinoma but not in synchronous liver adenoma

S F Ding; R P Jalleh; J Dooley; C B Wood; N A Habib

Chromosome 17 allele loss in hepatocellular carcinoma but not in synchronous liver adenoma

Eur J Surg Oncol. 1993 Apr;19(2):195-7.

Authors

S F Ding¹, R P Jalleh, J Dooley, C B Wood, N A Habib

Affiliation

¹ Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

PMID: 8387935

Abstract

A 51-year-old female underwent resection of two synchronous liver tumours, a hepatocellular carcinoma and an adenoma. DNA analysis revealed allele loss on chromosome 17 (17p13, near the locus of p53 tumour suppressor gene) in the hepatocellular carcinoma but not in the adenoma. This finding may support the view that loss of p53 tumour suppressor gene is associated with tumour progression.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Hepatocellular / genetics*
Chromosome Deletion*
Chromosomes, Human, Pair 17*
Female
Genes, p53 / genetics
Humans
Liver Neoplasms / genetics*
Middle Aged
Neoplasms, Multiple Primary / genetics*