Tumor viruses in CD30-positive anaplastic large cell lymphomas

Leuk Lymphoma. 1993 Mar;9(4-5):321-8. doi: 10.3109/10428199309148529.

Abstract

CD30+ anaplastic large cell lymphoma (ALCL) represents a novel lymphoma entity at the borderline between Hodgkin's disease and non-Hodgkin's lymphomas. Phenotypic, genotypic, and karyotypic analyses have shown that ALCL are heterogeneous in cellular origin, and may be conceived as malignancies derived from activated, mainly T- or B-lymphoid cells, in some instances with an immature genotype. Epstein-Barr virus genomes and gene products, most notably the transformation-associated latent membrane protein (LMP), have been detected in a proportion of cases, and some cutaneous ALCL proved to harbor complete or incomplete HTLV-1 proviruses. These findings suggest that both EBV and HTLV-I, which are powerful inducers of CD30 expression in lymphoid cells in vitro, may contribute to the pathoetiology of ALCL.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Aged
  • Antibodies, Monoclonal / immunology
  • Antigens, CD / analysis*
  • Antigens, CD / biosynthesis
  • Antigens, Neoplasm / analysis*
  • Antigens, Neoplasm / biosynthesis
  • Carcinoma / chemistry
  • Carcinoma / microbiology
  • DNA, Viral / analysis
  • Gene Expression Regulation, Neoplastic
  • Gene Expression Regulation, Viral
  • HTLV-I Infections / microbiology
  • Herpesvirus 4, Human / genetics
  • Herpesvirus 4, Human / isolation & purification*
  • Herpesvirus 4, Human / pathogenicity
  • Human T-lymphotropic virus 1 / genetics
  • Human T-lymphotropic virus 1 / isolation & purification*
  • Human T-lymphotropic virus 1 / pathogenicity
  • Humans
  • Ki-1 Antigen
  • Lymphocyte Activation
  • Lymphoma, Large B-Cell, Diffuse / classification
  • Lymphoma, Large B-Cell, Diffuse / microbiology*
  • Middle Aged
  • Nasopharyngeal Neoplasms / chemistry
  • Nasopharyngeal Neoplasms / microbiology
  • Neoplasm Proteins / analysis*
  • Neoplasm Proteins / biosynthesis
  • Neoplastic Stem Cells / metabolism
  • Neoplastic Stem Cells / microbiology
  • Retroviridae Proteins / analysis
  • Retroviridae Proteins / genetics
  • Skin Neoplasms / microbiology*
  • Tumor Virus Infections / microbiology*
  • Viral Proteins / analysis

Substances

  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, Neoplasm
  • DNA, Viral
  • Ki-1 Antigen
  • Neoplasm Proteins
  • Retroviridae Proteins
  • Viral Proteins