Screening for the APP codon 670/671 mutations in Alzheimer's disease

H Houlden; F Crawford; M Rossor; M Mullan

doi:10.1016/0304-3940(93)90196-r

Screening for the APP codon 670/671 mutations in Alzheimer's disease

Neurosci Lett. 1993 May 14;154(1-2):161-2. doi: 10.1016/0304-3940(93)90196-r.

Authors

H Houlden¹, F Crawford, M Rossor, M Mullan

Affiliation

¹ Department of Biochemistry, St. Mary's Hospital Medical School, Paddington, London, UK.

PMID: 8395665
DOI: 10.1016/0304-3940(93)90196-r

Abstract

A mutation at codons 670 and 671 of exon 16 of the amyloid precursor protein has recently been identified as a cause of early onset familial Alzheimer's disease. Using restriction enzyme digestion, screening failed to reveal the occurrence of this mutation in 43 families with early onset, 31 families with late onset, 30 cases of sporadic Alzheimer's disease or 30 clinically normal individuals.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Alzheimer Disease / genetics*
Amyloid beta-Protein Precursor / genetics*
Base Sequence
Codon / genetics*
DNA Restriction Enzymes
Exons / physiology
Humans
Middle Aged
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Polymerase Chain Reaction

Substances

Amyloid beta-Protein Precursor
Codon
DNA Restriction Enzymes