Localization of X chromosome short arm markers relative to synovial sarcoma- and renal adenocarcinoma-associated translocation breakpoints

Hum Genet. 1993 Oct 1;92(3):305-8. doi: 10.1007/BF00244478.

Abstract

A series of thirteen different DNA markers was mapped relative to papillary renal cell carcinoma- and synovial sarcoma-associated translocation breakpoints in Xp11.2 using a panel of tumor-derived somatic cell hybrids in conjunction with Southern blot analysis. Our results indicate that the two translocation breakpoints differ from each other and that the chromosomal break in t(X;1)-positive papillary renal cell carcinoma is located between the markers PFC-TIMP-OATL1-SYP-TFE3 and DXS226-DXS146-DXS255-OATL2-DXS14. In addition, our current breakpoint analysis has resulted in a revision of the regional localization of the proximal Xp marker DXS226.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blotting, Southern
  • Carcinoma, Renal Cell / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1*
  • Chromosomes, Human, Pair 18*
  • Cricetinae
  • Cricetulus
  • Genetic Markers
  • Humans
  • Hybrid Cells
  • Male
  • Sarcoma, Synovial / genetics*
  • Translocation, Genetic*
  • Tumor Cells, Cultured
  • X Chromosome*

Substances

  • Genetic Markers