Parental age, genetic mutation, and cerebral palsy

J Med Genet. 1993 Jan;30(1):44-6. doi: 10.1136/jmg.30.1.44.

Abstract

Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Athetosis
  • Birth Order
  • Cerebral Palsy / classification
  • Cerebral Palsy / genetics*
  • Cerebral Palsy / pathology
  • Dystonia
  • Genes, Dominant
  • Hemiplegia
  • Humans
  • Infant, Newborn
  • Maternal Age*
  • Middle Aged
  • Mutation*
  • Paralysis
  • Paternal Age*
  • Quadriplegia