The morquio A syndrome (mucopolysaccharidosis IVA) gene maps to 16q24.3

E Baker; X H Guo; A M Orsborn; G R Sutherland; D F Callen; J J Hopwood; C P Morris

The morquio A syndrome (mucopolysaccharidosis IVA) gene maps to 16q24.3

Am J Hum Genet. 1993 Jan;52(1):96-8.

Authors

E Baker¹, X H Guo, A M Orsborn, G R Sutherland, D F Callen, J J Hopwood, C P Morris

Affiliation

¹ Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, Australia.

PMID: 8434612
PMCID: PMC1682100

Abstract

The gene for N-acetylgalactosamine-6-sulfatase, the deficiency of which results in Morquio A syndrome (mucopolysaccharidosis type IVA), was assigned to chromosome 16 at band q24.3 by fluorescence in situ hybridization. Localization of this band was confirmed by PCR analysis of a somatic cell hybrid panel used for fine mapping of chromosome 16.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Base Sequence
Chondroitinsulfatases / deficiency
Chondroitinsulfatases / genetics*
Chromosome Mapping
Chromosomes, Human, Pair 16*
DNA, Single-Stranded
Humans
Hybrid Cells
In Situ Hybridization, Fluorescence
Male
Mice
Molecular Sequence Data
Mucopolysaccharidosis IV / genetics*
Polymerase Chain Reaction

Substances

DNA, Single-Stranded
Chondroitinsulfatases