Abstract
Using polymorphisms of the human leukocyte antigen (HLA) DQB1 gene, a case-control study was conducted in a group of patients with schizophrenia (DSM-III, n = 58) and psychiatrically normal controls matched for ethnicity (n = 72), living in the same geographical area. A significant negative association of allele HLA DQB1*0602 with schizophrenia was present among African-Americans (odds ratio 0.19), but could not be detected in Caucasians.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Alleles*
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Autoimmune Diseases / diagnosis
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Autoimmune Diseases / genetics
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Autoimmune Diseases / immunology
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Black People* / genetics
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Diabetes Mellitus, Type 1 / diagnosis
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Diabetes Mellitus, Type 1 / genetics
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Diabetes Mellitus, Type 1 / immunology
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Female
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Genetic Markers / genetics
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HLA-DQ Antigens / genetics*
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HLA-DQ beta-Chains
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Humans
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Male
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Middle Aged
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Models, Genetic
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Multigene Family / genetics
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Schizophrenia / diagnosis
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Schizophrenia / genetics*
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Schizophrenia / immunology
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Schizophrenic Psychology*
Substances
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Genetic Markers
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HLA-DQ Antigens
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HLA-DQ beta-Chains
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HLA-DQB1 antigen