Abstract
Polymerase chain reaction amplification of reverse transcription products has demonstrated the presence of abl-bcr hybrid mRNAs in RNA from peripheral blood leucocytes of Philadelphia-chromosome-positive chronic myeloid leukaemia patients; such hybrid mRNAs can contain either of the alternative first exons of c-abl. A survey of 12 CMLs has shown that abl-bcr mRNAs occur in the leucocytes of some, but not all, patients, and that they are present both in chronic-phase and acute-phase leucocytes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Chromosomes, Human, Pair 9
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DNA, Neoplasm / genetics
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Fusion Proteins, bcr-abl / genetics*
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Humans
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
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Molecular Sequence Data
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Oligodeoxyribonucleotides / chemistry
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Oncogenes
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Polymerase Chain Reaction
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RNA, Messenger / genetics
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RNA, Neoplasm / genetics
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Transcription, Genetic
Substances
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DNA, Neoplasm
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Oligodeoxyribonucleotides
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RNA, Messenger
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RNA, Neoplasm
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Fusion Proteins, bcr-abl