Abstract
Some recent aspects of the molecular biology of chromosome abnormalities that activate the BCL2 gene in B cell malignancies (follicular lymphoma, chronic lymphocytic leukemia) are discussed. We also report data showing that the Epstein-Barr virus (EBV) LMP-1 protein which can induce the expression of BCL2, is found infrequently in follicular lymphomas which exhibit no apparent BCL2 gene rearrangement.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigens, Viral / genetics
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Humans
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics
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Lymphoma, Non-Hodgkin / genetics*
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Oncogenes*
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins c-bcl-2
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Recombination, Genetic
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Translocation, Genetic
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Viral Matrix Proteins / genetics
Substances
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Antigens, Viral
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EBV-associated membrane antigen, Epstein-Barr virus
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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Viral Matrix Proteins