Abstract
In order to elucidate the role of macrophage in lipid-induced nephrotoxicity in diabetic nephropathy, we examined the effect of macrophage colony-stimulating factor (M-CSF) on the progression of renal lesions in hypercholesterolemic steptozotocin (STZ)-diabetic rats fed with high cholesterol chow. Hypercholesterolemia aggravated albuminuria in diabetic rats accompanied by infiltration of macrophages in glomeruli. Treatment with M-CSF suppressed simultaneously infiltration of glomerular macrophages and urinary albumin excretion in hypercholesterolemic diabetic rats. These results suggest that infiltration of glomerular macrophage has a primary role in lipid-induced nephrotoxicity in diabetic nephropathy, and M-CSF is involved in this process as a preventive factor.
MeSH terms
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Albuminuria / prevention & control
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Animals
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Body Weight / drug effects
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Cholesterol, Dietary / toxicity*
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Cholic Acid
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Cholic Acids / toxicity*
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Diabetes Mellitus, Experimental / complications
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Diabetes Mellitus, Experimental / pathology
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Diabetes Mellitus, Experimental / physiopathology*
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Diabetic Nephropathies / complications
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Diabetic Nephropathies / pathology
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Diabetic Nephropathies / physiopathology*
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Humans
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Hypercholesterolemia / complications
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Hypercholesterolemia / pathology
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Hypercholesterolemia / physiopathology*
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Hyperlipidemias / pathology
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Hyperlipidemias / physiopathology*
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Kidney / drug effects
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Kidney / pathology
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Kidney / physiopathology*
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Kidney Glomerulus / drug effects
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Kidney Glomerulus / pathology
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Macrophage Colony-Stimulating Factor / pharmacology*
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Macrophages / drug effects*
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Macrophages / pathology
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Male
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Organ Size / drug effects
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Rats
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Rats, Wistar
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Recombinant Proteins / pharmacology
Substances
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Cholesterol, Dietary
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Cholic Acids
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Recombinant Proteins
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Macrophage Colony-Stimulating Factor
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Cholic Acid