Cancer predisposition. Ataxia-telangiectasia at the crossroads

Curr Biol. 1995 Nov 1;5(11):1210-2. doi: 10.1016/s0960-9822(95)00238-7.

Abstract

ATM, the gene product mutated in the cancer susceptibility syndrome ataxia-telangiectasia, is related to proteins involved in DNA repair and cell-cycle control, perhaps explaining how ATM prevents carcinogenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Ataxia Telangiectasia / enzymology
  • Ataxia Telangiectasia / genetics*
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Proteins
  • DNA Repair
  • DNA-Activated Protein Kinase
  • DNA-Binding Proteins*
  • Humans
  • Neoplasms / enzymology
  • Neoplasms / genetics
  • Nuclear Proteins
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / metabolism
  • Proteins / genetics*
  • Proteins / metabolism
  • Tumor Suppressor Proteins

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Proteins
  • Tumor Suppressor Proteins
  • ATM protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • DNA-Activated Protein Kinase
  • PRKDC protein, human
  • Protein Serine-Threonine Kinases