Mutations in the p53 tumour suppressor gene in thyroid tumours of children from areas contaminated by the Chernobyl accident

S Hillebrandt; C Streffer; C Reiners; E Demidchik

doi:10.1080/095530096146165

Mutations in the p53 tumour suppressor gene in thyroid tumours of children from areas contaminated by the Chernobyl accident

Int J Radiat Biol. 1996 Jan;69(1):39-45. doi: 10.1080/095530096146165.

Authors

S Hillebrandt¹, C Streffer, C Reiners, E Demidchik

Affiliation

¹ Institut für Medizinische Strahlenbiologie, Universitätsklinikum Essen, Germany.

PMID: 8601754
DOI: 10.1080/095530096146165

Abstract

The number of p53 mutations observed in thyroid carcinomas derived from children from areas contaminated by Chernobyl accident is higher compared with studies on patients who had no contact with radioactivity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Carcinoma, Papillary / etiology
Carcinoma, Papillary / genetics*
Child
DNA, Neoplasm / genetics
DNA, Neoplasm / radiation effects
Electrophoresis / methods
Exons
Female
Gene Amplification
Genes, p53 / radiation effects*
Humans
Male
Neoplasms, Radiation-Induced / etiology
Neoplasms, Radiation-Induced / genetics*
Point Mutation*
Polymerase Chain Reaction
Power Plants*
Radioactive Hazard Release*
Thyroid Neoplasms / etiology
Thyroid Neoplasms / genetics*
Ukraine

Substances

DNA, Neoplasm