Eosinophilia associated with proliferation of CD(3+)4-(8-) alpha beta+ T cells with chromosome 16 anomalies

Br J Haematol. 1996 Feb;92(2):315-7. doi: 10.1046/j.1365-2141.1996.d01-1482.x.

Abstract

We describe a patient with eosinophilia and an abnormal CD(3+)4-(8-) alpha beta+ T-cell population. Chromosomal analysis of sorted CD(3+)4-(8-) cells revealed abnormal karyotypes on chromosome 16. In the presence of IL-2 the production of IL-5 from CD(3+)4-(8-) cells was higher than that from CD(3+)4-(8-) cells. Eosinophil survival-enhancing activity in the patient serum was inhibited by a combination of anti-IL-5 and anti-GM-CSF monoclonal antibodies. These data suggest that increased production of IL-5 and GM-CSF from the abnormal CD(3+)4-(8-) cells might cause eosinophilia.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal / pharmacology
  • CD3 Complex / immunology*
  • Cell Death / immunology
  • Cell Division / immunology
  • Cells, Cultured
  • Chromosomes, Human, Pair 16*
  • Eosinophilia / genetics
  • Eosinophilia / immunology*
  • Eosinophils / physiology
  • Granulocyte-Macrophage Colony-Stimulating Factor / immunology
  • Humans
  • Interleukin-2 / pharmacology
  • Interleukin-5 / immunology
  • Interleukin-5 / metabolism
  • Male
  • Middle Aged
  • Receptors, Antigen, T-Cell, alpha-beta / immunology*
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism
  • Translocation, Genetic / immunology*

Substances

  • Antibodies, Monoclonal
  • CD3 Complex
  • Interleukin-2
  • Interleukin-5
  • Receptors, Antigen, T-Cell, alpha-beta
  • Granulocyte-Macrophage Colony-Stimulating Factor