Abstract
We describe a patient with eosinophilia and an abnormal CD(3+)4-(8-) alpha beta+ T-cell population. Chromosomal analysis of sorted CD(3+)4-(8-) cells revealed abnormal karyotypes on chromosome 16. In the presence of IL-2 the production of IL-5 from CD(3+)4-(8-) cells was higher than that from CD(3+)4-(8-) cells. Eosinophil survival-enhancing activity in the patient serum was inhibited by a combination of anti-IL-5 and anti-GM-CSF monoclonal antibodies. These data suggest that increased production of IL-5 and GM-CSF from the abnormal CD(3+)4-(8-) cells might cause eosinophilia.
MeSH terms
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Antibodies, Monoclonal / pharmacology
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CD3 Complex / immunology*
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Cell Death / immunology
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Cell Division / immunology
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Cells, Cultured
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Chromosomes, Human, Pair 16*
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Eosinophilia / genetics
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Eosinophilia / immunology*
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Eosinophils / physiology
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Granulocyte-Macrophage Colony-Stimulating Factor / immunology
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Humans
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Interleukin-2 / pharmacology
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Interleukin-5 / immunology
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Interleukin-5 / metabolism
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Male
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Middle Aged
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Receptors, Antigen, T-Cell, alpha-beta / immunology*
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
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Translocation, Genetic / immunology*
Substances
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Antibodies, Monoclonal
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CD3 Complex
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Interleukin-2
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Interleukin-5
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Receptors, Antigen, T-Cell, alpha-beta
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Granulocyte-Macrophage Colony-Stimulating Factor