Abstract
Clinical drug resistance poses a major problem in the successful treatment of ovarian cancer. Two genes, MDR1 and MRP, have been found to play a role in the multidrug resistance phenotype of a number of human tumors. Using a sensitive semiquantitative PCR assay we examined 53 primary untreated ovarian tumors for expression of both MDR1 and MRP genes. Approximately one-third of the tumors expressed MDR1 while all the tumors expressed varying levels of the MRP gene.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics
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ATP-Binding Cassette Transporters / biosynthesis*
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ATP-Binding Cassette Transporters / genetics
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Drug Resistance, Multiple*
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Drug Resistance, Neoplasm
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Female
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Gene Expression
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Humans
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Multidrug Resistance-Associated Proteins
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Ovarian Neoplasms / genetics
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Ovarian Neoplasms / metabolism*
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Polymerase Chain Reaction
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Prognosis
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RNA, Neoplasm / analysis
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RNA, Neoplasm / genetics
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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ATP-Binding Cassette Transporters
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Multidrug Resistance-Associated Proteins
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RNA, Neoplasm