Abstract
Tax1 is essential for human T-cell lymphotropic virus type I (HTLV-I) virus replication and transformation. We have identified and characterized a Tax1 binding protein, TRX, by cDNA screening of a Jurkat T-cell cDNA library. TRX mRNA is ubiquitously expressed in human tissues tested and cell lines analyzed.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Carrier Proteins / genetics*
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Carrier Proteins / metabolism
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Cloning, Molecular
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DNA, Complementary / genetics*
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Gene Products, tax / metabolism*
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Genes*
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Human T-lymphotropic virus 1 / genetics*
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Humans
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Intracellular Signaling Peptides and Proteins*
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Leukemia-Lymphoma, Adult T-Cell / genetics
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Leukemia-Lymphoma, Adult T-Cell / pathology
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Lymphocytes / metabolism
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Membrane Proteins
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Molecular Sequence Data
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
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Tumor Cells, Cultured
Substances
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Carrier Proteins
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DNA, Complementary
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Gene Products, tax
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Intracellular Signaling Peptides and Proteins
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Membrane Proteins
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RNA, Messenger
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VAC14 protein, human