Developmental immunohistochemistry of the 22 kDa peroxisomal membrane protein in the human brain

T Miyawaki; O Sohma; Y Suzuki; S Takashima

doi:10.1016/0006-8993(95)01053-x

Developmental immunohistochemistry of the 22 kDa peroxisomal membrane protein in the human brain

Brain Res. 1995 Nov 27;700(1-2):285-8. doi: 10.1016/0006-8993(95)01053-x.

Authors

T Miyawaki¹, O Sohma, Y Suzuki, S Takashima

Affiliation

¹ Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Tokyo, Japan.

PMID: 8624723
DOI: 10.1016/0006-8993(95)01053-x

Abstract

We studied immunohistochemically the 22 kDa peroxisomal membrane protein (PMP 22). In the control brain, the immunopositive neurons for PMP 22 appeared 2-3 weeks earlier than those for peroxisomal enzymes. PMP 22-immunopositive glial cells appeared at 26-27 gestational weeks, increased with gestational age, and were rarely recognized after 1 year of age. In the patients with Zellweger syndrome, PMP 22-immunoreactivity was recognized in neurons, glias, liver and kidney cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Brain / embryology
Brain / growth & development
Brain / metabolism*
Cerebellum / chemistry
Embryonic and Fetal Development / physiology
Frontal Lobe / chemistry
Gestational Age
Humans
Immunohistochemistry
Infant
Kidney / chemistry
Kidney / cytology
Liver / chemistry
Liver / cytology
Membrane Proteins / analysis*
Microbodies / chemistry*
Molecular Weight
Neuroglia / chemistry
Neurons / chemistry
Organ Specificity / physiology

Substances

Membrane Proteins
PXMP2 protein, human