Abstract
El mouse is a mutant which has epileptic convulsions after tossing-up stimulations and has a hippocampal dysfunction. Platelet-derived growth factor B-chain homodimer has been reported to be a trophic factor of hippocampal neurons. We found that a recombinant PDGF-BB suppressed the convulsions of El mice in a dose-dependent manner. Furthermore, thrombin-treated mice manifested no convulsions, but thrombin receptor activating peptide-treated ones had convulsions. These findings suggest that an abnormality in PDGF-BB release may make El mice susceptible to tonic-clonic convulsions.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticonvulsants / pharmacology*
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Becaplermin
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Disease Models, Animal
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Epilepsy, Tonic-Clonic / genetics
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Epilepsy, Tonic-Clonic / prevention & control*
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Humans
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Male
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Mice
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Mice, Neurologic Mutants
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Oligopeptides / pharmacology
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Platelet-Derived Growth Factor / pharmacology*
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Proto-Oncogene Proteins c-sis
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Receptors, Thrombin
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Recombinant Proteins / pharmacology
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Seizures / genetics
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Seizures / prevention & control*
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Thrombin / pharmacology
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Time Factors
Substances
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Anticonvulsants
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Oligopeptides
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Platelet-Derived Growth Factor
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Proto-Oncogene Proteins c-sis
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Receptors, Thrombin
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Recombinant Proteins
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platelet-derived growth factor A
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thrombin receptor-activating peptide SFLLRNPNDKY
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Becaplermin
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Thrombin