Transient hypertrophic cardiomyopathy is a rare sequela of both glucocorticoid and insulin excess. We report two ELBW infants who developed hypertrophic cardiomyopathy as an iatrogenic complication of the concurrent therapeutic administration of a glucocorticoid and insulin. In both cases the hypertrophic cardiomyopathy resolved completely on cessation of therapy. We advise caution when using this therapeutic combination and stress the need for regular echocardiography.