Marked bone marrow eosinophilia at the time of relapse of acute myeloblastic leukaemia in association with the appearance of translocation t(12;20)(q24;q11)

F Partridge; W Richardson; P Kearns; R Wilcox; G Majumdar

doi:10.3109/10428199609051747

Marked bone marrow eosinophilia at the time of relapse of acute myeloblastic leukaemia in association with the appearance of translocation t(12;20)(q24;q11)

Leuk Lymphoma. 1996 Jun;22(1-2):181-2. doi: 10.3109/10428199609051747.

Authors

F Partridge¹, W Richardson, P Kearns, R Wilcox, G Majumdar

Affiliation

¹ Haematology Department, George Eliot Hospital, Nuneaton, England.

PMID: 8724547
DOI: 10.3109/10428199609051747

Abstract

We report a case of acute myeloblastic leukaemia (AML), FAB type M2, with karyotype t(8;21)(q22;q22), who at the time of relapse showed marked eosinophilia of the bone marrow. Karyotype analysis showed the appearance of an additional clone t(8;21)(q22;q22),t(12;20)(q24;q11). To the best of our knowledge, marked eosinophilia has not been reported in association with this particular chromosomal translocation.

Publication types

Case Reports

MeSH terms

Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Bone Marrow / pathology*
Chromosomes, Human, Pair 12 / ultrastructure*
Chromosomes, Human, Pair 20 / ultrastructure*
Chromosomes, Human, Pair 21 / ultrastructure
Chromosomes, Human, Pair 8 / ultrastructure
Cytarabine / administration & dosage
Daunorubicin / administration & dosage
Eosinophilia / etiology*
Eosinophilia / genetics
Eosinophilia / pathology
Etoposide / administration & dosage
Humans
Idarubicin / administration & dosage
Leukemia, Myeloid, Acute / complications*
Leukemia, Myeloid, Acute / drug therapy
Leukemia, Myeloid, Acute / genetics
Leukemia, Myeloid, Acute / pathology
Male
Neoplasm Recurrence, Local
Remission Induction
Translocation, Genetic*

Substances

Cytarabine
Etoposide
Idarubicin
Daunorubicin