Abstract
Loss of heterozygosity (LOH) was studied in 10 primary retinoblastoma tumors in the VNTR region of intron 1 in p53 gene by the polymerase chain reaction. To our knowledge mutations have not been reported in the p53 gene in retinoblastoma primary tumors. Heterozygosity was found at this region in 5 of 10 cases. Two pathology paraffin block samples showed loss of heterozygosity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alleles
-
Base Sequence
-
DNA Primers
-
Eye Neoplasms / genetics*
-
Eye Neoplasms / pathology
-
Genes, Retinoblastoma
-
Genes, p53*
-
Genetic Variation
-
Humans
-
Introns*
-
Male
-
Minisatellite Repeats*
-
Molecular Sequence Data
-
Polymerase Chain Reaction
-
Retinoblastoma / genetics*
-
Retinoblastoma / pathology
-
Sequence Deletion*
-
Turkey