Lineage-specific CaN19 expression in human skin: lack of expression in normal melanocytes

J Dermatol Sci. 1996 Apr;12(1):69-72. doi: 10.1016/0923-1811(95)00497-1.

Abstract

Although expression of CaN19 is reduced in cell lines derived from tumors of diverse origin, its expression in their normal counterparts has not been studied in detail. We find that CaN19 mRNA is expressed at very low to undetectable levels in normal melanocytes as well as malignant melanoma cell lines, confirming that CaN19 expression in normal cells is lineage-dependent.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cells, Cultured
  • Fibroblasts / metabolism
  • Gene Expression*
  • Genes, Tumor Suppressor*
  • Humans
  • Keratinocytes / metabolism
  • Melanocytes / metabolism*
  • Melanoma / genetics
  • Melanoma / metabolism
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Skin / cytology
  • Skin / metabolism*
  • Tumor Cells, Cultured

Substances

  • RNA, Messenger