7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures

Eur J Pharmacol. 1995 Dec 12;287(2):211-3. doi: 10.1016/0014-2999(95)00678-8.

Abstract

7-Nitro indazole (25-100 mg/kg i.p.), an inhibitor of neuronal nitric oxide (NO) synthase, attenuated the severity of pilocarpine (300 mg/kg i.p.)-induced seizures in mice. This indicates that the decreased neuroexcitability of the central nervous system (CNS) following administration of 7-nitro indazole may be due to inhibition of neuronal NO synthase, implying that NO acts as an excitatory and proconvulsant factor in the CNS.

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / pharmacology
  • Indazoles / pharmacology*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Motor Activity / drug effects
  • Nitric Oxide Synthase / drug effects*
  • Pilocarpine / pharmacology*
  • Seizures / drug therapy*

Substances

  • Enzyme Inhibitors
  • Indazoles
  • Pilocarpine
  • Nitric Oxide Synthase