Abstract
Patients diagnosed using DSM-III-R criteria as having schizophrenia and other related disorders (n = 128) were assessed for CGG trinucleotide repeat expansion in the fragile X mental retardation 1 (FMR-1) gene. One subject, a woman with schizophreniform disorder, was found to have a premutation of the gene. Her case report is given. The present investigation supports the view that mutation or premutation of the FMR-1 gene is not of importance for the aetiology of the vast majority of schizophrenic patients.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Base Sequence
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Blotting, Southern
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DNA / blood
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DNA / isolation & purification
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Female
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Fragile X Mental Retardation Protein
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Fragile X Syndrome / genetics*
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Humans
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Male
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Middle Aged
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Nerve Tissue Proteins / genetics*
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Nuclear Family
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Pedigree
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RNA-Binding Proteins / genetics
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Repetitive Sequences, Nucleic Acid*
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Schizophrenia / genetics*
Substances
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FMR1 protein, human
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Nerve Tissue Proteins
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RNA-Binding Proteins
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Fragile X Mental Retardation Protein
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DNA