An endometrial polyp with a rearrangement of HMGI-C underlying a complex cytogenetic rearrangement involving chromosomes 2 and 12

Cancer Genet Cytogenet. 1996 Aug;90(1):88-90. doi: 10.1016/0165-4608(96)00062-3.

Abstract

Cytogenetic studies of an endometrial polyp of an 82-year-old patient revealed a karyotype 46,XX,der(2)inv(2)(p25q21)ins(2;12)(p25;q13q14)t(2;12)(q21; q15),der(12)del(12)(q13q14)del(12)(q15). By fluorescence in situ hybridization (FISH) we found the chromosome 12 translocation breakpoint to be mapping within the third intron of the HMGI-C gene also harboring the breakpoints of translocations involving 12q15 seen in uterine leiomyomas, lipomas, pleomorphic adenomas, and pulmonary chondroid hamartomas.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma
  • Aged
  • Aged, 80 and over
  • Chromosomes, Human, Pair 12 / genetics
  • Chromosomes, Human, Pair 12 / ultrastructure*
  • Chromosomes, Human, Pair 2 / genetics
  • Chromosomes, Human, Pair 2 / ultrastructure*
  • Endometrial Neoplasms / genetics*
  • Female
  • HMGA2 Protein
  • High Mobility Group Proteins / genetics
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Leiomyoma
  • Neoplasm Proteins / genetics
  • Neoplasms, Multiple Primary
  • Polyps / genetics*
  • Translocation, Genetic*
  • Uterine Neoplasms

Substances

  • HMGA2 Protein
  • High Mobility Group Proteins
  • Neoplasm Proteins