An investigation to determine whether clusters of cancer types exist in nine breast-ovary families

Genet Epidemiol. 1995;12(6):841-6. doi: 10.1002/gepi.1370120652.

Abstract

Monte-Carlo simulations were carried out on nine BRCA1-linked families selected from the 1993 Breast Cancer Linkage Consortium. These families all displayed a prevalence of both breast and ovarian cancers, but little evidence was found to conclude that sufferers of either type formed clusters in particular branches of families. It was noted that the application of these methods to larger pedigrees with known probands would be useful in further clarifying the issue.

MeSH terms

  • Age of Onset
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / genetics*
  • Chromosomes, Human, Pair 17*
  • Cluster Analysis
  • Computer Simulation*
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Monte Carlo Method*
  • Ovarian Neoplasms / epidemiology
  • Ovarian Neoplasms / genetics*
  • Pedigree
  • Prevalence
  • Risk Factors