Disease mechanism: unravelling Wiskott-Aldrich syndrome

Curr Biol. 1996 Jun 1;6(6):676-8. doi: 10.1016/s0960-9822(09)00447-3.

Abstract

The gene responsible for Wiskott-Aldrich syndrome, a disease affecting platelets and lymphocytes, has been cloned and its protein product (WASp) found to interact with the GTPase Cdc42. WASp seems to provide a link between Cdc42 and the actin cytoskeleton, perhaps explaining the cellular defects underlying the disease.

Publication types

  • Review

MeSH terms

  • Cell Cycle Proteins / metabolism*
  • GTP-Binding Proteins / metabolism*
  • Humans
  • Proteins / genetics
  • Proteins / metabolism*
  • Wiskott-Aldrich Syndrome / metabolism*
  • Wiskott-Aldrich Syndrome Protein
  • cdc42 GTP-Binding Protein

Substances

  • Cell Cycle Proteins
  • Proteins
  • WAS protein, human
  • Wiskott-Aldrich Syndrome Protein
  • GTP-Binding Proteins
  • cdc42 GTP-Binding Protein