Evidence for a fourth locus in Usher syndrome type I

S Gerber; D Larget-Piet; J M Rozet; D Bonneau; M Mathieu; V Der Kaloustian; A Munnich; J Kaplan

doi:10.1136/jmg.33.1.77

Evidence for a fourth locus in Usher syndrome type I

J Med Genet. 1996 Jan;33(1):77-9. doi: 10.1136/jmg.33.1.77.

Authors

S Gerber¹, D Larget-Piet, J M Rozet, D Bonneau, M Mathieu, V Der Kaloustian, A Munnich, J Kaplan

Affiliation

¹ Unité de Recherches sur les Handicaps Génétiques de l'Enfant, INSERM U393, Hôpital des Enfants Malades, Paris, France.

Abstract

Usher syndrome type I (US1) is an autosomal recessive condition in which three different genes have been already localised (USH1A, USH1B, and USH1C on chromosomes 14q32, 11q13, and 11p15 respectively). The genetic heterogeneity of US1 has been confirmed in a previous study by linkage analysis of 20 French pedigrees. Here, we report the genetic exclusion of the three previously reported loci in two large multiplex families of Moroccan and Pakistani origin, suggesting the existence of at least a fourth locus in Usher syndrome type I.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abnormalities, Multiple / genetics*
Chromosome Mapping*
Female
Hearing Loss, Sensorineural / congenital
Hearing Loss, Sensorineural / genetics*
Humans
Male
Pedigree
Retinitis Pigmentosa / congenital
Retinitis Pigmentosa / genetics*
Speech Disorders / genetics*
Syndrome
Vestibular Diseases / genetics*