Abstract
Apo-E genotype was not significantly related to cognitive performance in 157 Alzheimer's disease patients. However, patients homozygous for the epsilon 4 allele appeared most impaired on global cognition but least impaired on language measures. Further study with larger samples may reveal that Apo-E genotype accounts for some of the variability in cognitive deficits observed in Alzheimer's disease.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Alleles
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Alzheimer Disease / genetics*
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Alzheimer Disease / psychology*
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Apolipoproteins E / genetics
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Apolipoproteins E / metabolism*
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Cognition Disorders / genetics*
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Cognition Disorders / psychology*
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Female
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Genotype
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Humans
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Language Disorders / genetics*
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Language Disorders / psychology*
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Language Tests
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Male
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Middle Aged
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Neuropsychological Tests