HindIII DNA polymorphism in the lipoprotein lipase gene and plasma lipid phenotypes and carotid artery atherosclerosis

Hum Genet. 1996 Nov;98(5):551-6. doi: 10.1007/s004390050258.

Abstract

Lipoprotein lipase (LPL) is the rate limiting enzyme in the hydrolysis of core triglyceride in chylomicron and very low density lipoprotein (VLDL) thus affecting a broad spectrum of plasma lipid levels. In this paper, we investigated the association of a HindIII polymorphism in the LPL gene with plasma lipid levels and carotid artery wall thickness measured by B-mode ultrasonography. A total of 238 Caucasian subjects were selected from the Atherosclerosis Risk In Community (ARIC) study (male = 1.31, female = 107) based on their fasting triglyceride and LDL-cholesterol levels: normolipidemic (n = 48), hypertriglyceridemic (n = 44), hypercholesterolemic (n = 36), and hypertriglyceridemic-hypercholesterolemic (n = 110) groups. We observed a marginally significant association between lipid phenotypes and HindIII genotypes (P = 0.04) in males, with the hypertriglyceridemic and hypercholesterolemic groups having a higher frequency (0.65) of the H+H+ genotype than the other two groups (pooled: 0.55). In males, there was also a significant association between HindIII genotypes and carotid artery wall thickness after considering the effects of age, body mass index, cigarette smoking, lipid phenotype and diabetes status (P = 0.013), with the H+H+ genotype having a higher average value of carotid artery wall thickness (0.84 +/- 0.15 mm) than the other two genotype groups (0.76 +/- 0.14 mm in H+H(+)-genotype class, 0.75 +/- 0.13 mm in H-H- genotype class). In females, no significant associations among LPL HindIII genotype, lipid phenotype and carotid artery wall thickness were observed. These results suggest that the LPL HindIII polymorphism influences LPL-catalyzed, triglyceride-rich lipoprotein metabolism and carotid artery atherosclerosis in a gender-specific manner.

MeSH terms

  • Adult
  • Alcohol Drinking
  • Arteriosclerosis / genetics*
  • Body Mass Index
  • Carotid Arteries
  • Cholesterol / blood
  • DNA
  • Deoxyribonuclease HindIII
  • Female
  • Genotype
  • Humans
  • Hypertension / complications
  • Lipids / blood*
  • Lipoprotein Lipase / genetics*
  • Male
  • Middle Aged
  • Phenotype
  • Polymorphism, Genetic*
  • Smoking
  • Triglycerides / blood

Substances

  • Lipids
  • Triglycerides
  • DNA
  • Cholesterol
  • Lipoprotein Lipase
  • Deoxyribonuclease HindIII