Abstract
We examined the influence of apolipoprotein E (apoE) genotype on risk of dementia in 82 adults with Down's syndrome (DS). Compared with those with an apoE 3/3 genotype, the group of adults with DS with apoE 2/4, 3/4, and 4/4 genotypes were 5 times more likely to become demented (RR = 4.7; 95% CI = 1.2, 17.9). We hypothesize that the increased risk of dementia may be mediated by exacerbation of beta-amyloid deposition.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Apolipoprotein E4
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Apolipoproteins E / blood
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Apolipoproteins E / genetics*
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Dementia / epidemiology
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Dementia / etiology
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Dementia / genetics*
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Down Syndrome / genetics*
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Down Syndrome / psychology*
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Female
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Genotype
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Humans
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Incidence
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Male
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Middle Aged
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Risk Assessment
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Risk Factors
Substances
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Apolipoprotein E4
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Apolipoproteins E