Abstract
The genotypes of the ALDH2 and CYP2E1 loci of Japanese alcoholic patients were determined to investigate the susceptibility to alcoholic liver injury. In alcoholics with a liver-function disorder, a significant association was observed between the genotypes of the CYP2E1 loci and the serum level of a liver-derived enzyme, LAP. However, there was no significant association between the ALDH2 genotypes and liver dysfunction.
MeSH terms
-
Alcoholism / enzymology
-
Alcoholism / genetics*
-
Alcoholism / physiopathology
-
Aldehyde Dehydrogenase / genetics
-
Aldehyde Dehydrogenase, Mitochondrial
-
Alleles
-
Asian People / genetics*
-
Cytochrome P-450 CYP2E1 / genetics*
-
Genotype
-
Humans
-
Japan
-
Leucyl Aminopeptidase / blood*
-
Liver / enzymology
-
Liver / physiopathology
-
Liver Diseases, Alcoholic / enzymology
-
Liver Diseases, Alcoholic / genetics*
-
Liver Diseases, Alcoholic / physiopathology
Substances
-
Cytochrome P-450 CYP2E1
-
ALDH2 protein, human
-
Aldehyde Dehydrogenase
-
Aldehyde Dehydrogenase, Mitochondrial
-
Leucyl Aminopeptidase