Analysis of the candidate gene NRAMP1 in the first 61 ARC National Repository families for rheumatoid arthritis

J Rheumatol. 1997 Jan;24(1):212-4.

Abstract

Maximum likelihood identity-by-descent (IBD) sib pair analysis using a 3 locus haplotype NRAMP1-IL8RB-VIL1, or NRAMP1 alone, provided preliminary evidence (maximum LOD score = 1.01, p = 0.024) for a gene in this region of human chromosome 2q35 contributing to susceptibility to rheumatoid arthritis (RA). Candidacy for NRAMP1 as the disease susceptibility gene was supported by a significant bias (p < 0.048) toward transmission of the NRAMP1 promoter region allele 3 in affected offspring.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Arthritis, Rheumatoid / genetics*
  • Carrier Proteins / genetics*
  • Cation Transport Proteins*
  • Female
  • Gene Expression Regulation
  • Genes / genetics
  • HLA Antigens / genetics
  • Haplotypes
  • Humans
  • Male
  • Membrane Proteins / genetics*
  • Repetitive Sequences, Nucleic Acid

Substances

  • Carrier Proteins
  • Cation Transport Proteins
  • HLA Antigens
  • Membrane Proteins
  • natural resistance-associated macrophage protein 1