Translocation (9;17) a novel translocation in acute myeloid leukaemia

Leuk Res. 1996 Nov-Dec;20(11-12):987-8. doi: 10.1016/s0145-2126(96)00065-3.

Abstract

We report a case of AML, acute myeloid leukaemia, with a novel translocation involving the short arms of chromosomes 9 and 17. The acute myeloid leukaemia was morphologically classified as FAB subtype M2. A prolonged remission was induced with chemotherapy, followed by a relapse which was associated with the finding of the same translocation.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Chromosomes, Human, Pair 17 / genetics
  • Chromosomes, Human, Pair 17 / ultrastructure*
  • Chromosomes, Human, Pair 9 / genetics
  • Chromosomes, Human, Pair 9 / ultrastructure*
  • Cyclophosphamide / administration & dosage
  • Cytarabine / administration & dosage
  • Daunorubicin / administration & dosage
  • Genes, Tumor Suppressor
  • Humans
  • Leukemia, Myeloid, Acute / drug therapy
  • Leukemia, Myeloid, Acute / genetics*
  • Male
  • Prednisone / administration & dosage
  • Recurrence
  • Remission Induction
  • Salvage Therapy
  • Thioguanine / administration & dosage
  • Translocation, Genetic*
  • Vincristine / administration & dosage

Substances

  • Cytarabine
  • Vincristine
  • Cyclophosphamide
  • Thioguanine
  • Prednisone
  • Daunorubicin

Supplementary concepts

  • DAT-COAP regimen