RAB GTPases expressed in human melanoma cells

D Chen; J Guo; W A Gahl

doi:10.1016/s0167-4889(96)00169-3

RAB GTPases expressed in human melanoma cells

Biochim Biophys Acta. 1997 Jan 10;1355(1):1-6. doi: 10.1016/s0167-4889(96)00169-3.

Authors

D Chen¹, J Guo, W A Gahl

Affiliation

¹ Section on Human Biochemical Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1830, USA.

PMID: 9030196
DOI: 10.1016/s0167-4889(96)00169-3

Abstract

The expression of small GTP-binding protein genes of the ras superfamily was examined in pigmented human melanoma cells by a PCR-based strategy. Twenty six different partial cDNA sequences were isolated, including 17 members of the rab subfamily, of which 9 represented novel genes. Some rabs expressed in melanoma cells overlapped with those of platelets: this should prove relevant to the investigation of murine and human disorders characterized by the combination of pigment dilution and a platelet storage pool defect.

MeSH terms

Amino Acid Sequence
Animals
Base Sequence
Blood Platelets / chemistry
DNA, Complementary
GTP Phosphohydrolases / analysis
GTP Phosphohydrolases / genetics*
GTP-Binding Proteins / analysis
GTP-Binding Proteins / genetics*
Gene Expression
Humans
Melanoma / chemistry
Melanoma / genetics*
Molecular Sequence Data
Polymerase Chain Reaction
Tumor Cells, Cultured

Substances

DNA, Complementary
GTP Phosphohydrolases
GTP-Binding Proteins

Associated data

GENBANK/U66621
GENBANK/U66622
GENBANK/U66623
GENBANK/U66624