The receptor for the cytotoxic ligand TRAIL

Science. 1997 Apr 4;276(5309):111-3. doi: 10.1126/science.276.5309.111.

Abstract

TRAIL (also known as Apo-2L) is a member of the tumor necrosis factor (TNF) ligand family that rapidly induces apoptosis in a variety of transformed cell lines. The human receptor for TRAIL was found to be an undescribed member of the TNF-receptor family (designated death receptor-4, DR4) that contains a cytoplasmic "death domain" capable of engaging the cell suicide apparatus but not the nuclear factor kappa B pathway in the system studied. Unlike Fas, TNFR-1, and DR3, DR4 could not use FADD to transmit the death signal, suggesting the use of distinct proximal signaling machinery. Thus, the DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Amino Acid Sequence
  • Apoptosis Regulatory Proteins
  • Apoptosis*
  • Carrier Proteins / metabolism
  • Cell Line
  • Fas-Associated Death Domain Protein
  • Humans
  • Ligands
  • Membrane Glycoproteins / metabolism*
  • Molecular Sequence Data
  • NF-kappa B / metabolism
  • Proteins / metabolism
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Receptor-Interacting Protein Serine-Threonine Kinases
  • Receptors, TNF-Related Apoptosis-Inducing Ligand
  • Receptors, Tumor Necrosis Factor / chemistry
  • Receptors, Tumor Necrosis Factor / genetics
  • Receptors, Tumor Necrosis Factor / metabolism*
  • Recombinant Fusion Proteins / metabolism
  • Signal Transduction
  • TNF Receptor-Associated Factor 1
  • TNF-Related Apoptosis-Inducing Ligand
  • Transfection
  • Tumor Cells, Cultured
  • Tumor Necrosis Factor-alpha / metabolism*

Substances

  • Adaptor Proteins, Signal Transducing
  • Apoptosis Regulatory Proteins
  • Carrier Proteins
  • FADD protein, human
  • Fas-Associated Death Domain Protein
  • Ligands
  • Membrane Glycoproteins
  • NF-kappa B
  • Proteins
  • RNA, Messenger
  • Receptors, TNF-Related Apoptosis-Inducing Ligand
  • Receptors, Tumor Necrosis Factor
  • Recombinant Fusion Proteins
  • TNF Receptor-Associated Factor 1
  • TNF-Related Apoptosis-Inducing Ligand
  • TNFRSF10A protein, human
  • TNFSF10 protein, human
  • Tumor Necrosis Factor-alpha
  • RIPK1 protein, human
  • Receptor-Interacting Protein Serine-Threonine Kinases

Associated data

  • GENBANK/U90875