Abstract
Hybridization studies of mRNA link genetic with neurochemical and neuropathological approaches to Alzheimer's disease (AD). Here we review the distribution and abundance of amyloid precursor protein mRNAs in normal and AD-afflicted brains. The expression of apolipoprotein E and presenilin mRNAs are also discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alzheimer Disease / metabolism*
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Amyloid beta-Protein Precursor / genetics*
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Animals
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Apolipoproteins E / genetics
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Humans
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Membrane Proteins / genetics
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Presenilin-1
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Presenilin-2
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RNA, Messenger / metabolism*
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Tissue Distribution
Substances
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Amyloid beta-Protein Precursor
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Apolipoproteins E
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Membrane Proteins
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PSEN1 protein, human
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PSEN2 protein, human
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Presenilin-1
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Presenilin-2
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RNA, Messenger